Bachground & Aim: The presence of immunocompetent cells and various classes of immunoglobulins in inflamed pulps, indicates that host immune responces could participate in the pathogenesis of pulpitis. The purpose of this syudy was to determine the changes of immunoglobulins in the supernstsnt fluids of the explant cultures of various states of dental pulps.
Methods & Materials: For this purpose pulps of impacted teeth: were culyure with also healthy erupted teeth, teeth with irreversible symptomatic pulpitis and irreversible asymptomatic pulpitis were cultured. The amounts of various classes of immunoglobulins were measured by SRID method.
Results: The presence of IgG in the above states were 62.5% , 26.7%, 60% and 100% with average concentration of 833.5±944.5, 81.1±206, 23.6±30.6 and 786.5±799.5 mg/100ml respectively. The differences between these groups regard to concentration of IgG were significant (P<0.002).
The presence of IgA were observed in 50%. 6.7%, 10% and 100% with average concentration of 213.1±257.6, 31.1±121.6, 4.25±13.3 and 282.7±212.2 mg/100ml, respectively. There was also significant differences between the above groups for their IgA concentration (P<0.001).
IgM was present in 6.2%, 26.7%, 30% and 0% with average concentration of 0, 54.7±132.2, 20±32.7 and 0mg/100ml, respectively and the differences between these four groups were significant (P<0.05).
Conclusion: In conclusion, there are significant differences between the pulps of impacted and healthy erupted teeth, regard to presence and amounts of immunoglobulins.
J Dent Sch 2003 21(1): 44