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:: Volume 21, Issue 4 (Winter (Special Issue) 2004) ::
J Dent Sch GYEAR__, 21(4): 795-802 Back to browse issues page
Role of Apoptosis in periodontal disease: chronic and aggressive
Shahram Vaziri Corresponding Author: Dr. * 1, Roozbeh Khosravi Dr., Behnam Eslami Dr., Shirin Karimi Dr., Fateme Mashhadi Abbas Dr.
Abstract:   (7014 Views)

Background & Aim: Apoptosis is an evolutionary form of physiological cell death. Although numerous investigations have suggested that apoptosis is involved in the pathogenesis of diseases such as Rheumatoid Arthritis, Neurodegenerative diseases and cancer, the effect of apoptosis in periodontal disease still unknown. Therefore, we studied the apoptotic events in periodontally diseased gingival tissue.

Method & Materials: Gingival tissue biopsies from 15 patients with aggressive periodontitis, 15 patients with sever chronic periodontitis, and 15 healthy control, were obtained. Criteria for patients’ inclusion matched with classification of periodontal diseases. The control group included subjects with no prior history of periodontal diseases. The expression of Fas and Bcl-2 receptor were determined by Immunohistochemistry technique.

Results: Positive staining for Fas and Bc-2 receptor in sever chronic periodontitis was observed. (3.86±2.69 %) (36.57±6.24%). In aggressive periodontitis, positive staining for Fas and Bcl-2 receptor was observed (37.73%) (68.34 %). The differences between groups were significant (Mann-Whitney test P value < 0.05).

Conclusion: Our finding established that apoptosis is included in periodontal tissue by host or microbial factors and support the hypothesis that apoptotic mechanism could be implicated in inflammatory process associated with gingival tissue degeneration observed in periodontitis. Indeed, apoptosis has strong effects in sever destruction in aggressive periodontitis.

J Dent Sch 2004 21(Special Issue): 795

Keywords: Apoptosis, Periodontal Disease, Aggressive Periodontitis, Chronic Periodontitis
Full-Text [PDF 244 kb]   (1616 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2006/09/6
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Vaziri S, Khosravi R, Eslami B, Karimi S, Mashhadi Abbas F. Role of Apoptosis in periodontal disease: chronic and aggressive . J Dent Sch. 2004; 21 (4) :795-802
URL: http://jds.sbmu.ac.ir/article-1-638-en.html

Volume 21, Issue 4 (Winter (Special Issue) 2004) Back to browse issues page
مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی Shahid Beheshti University Dental Journal
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