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:: Volume 21, Issue 4 (Winter (Special Issue) 2004) ::
J Dent Sch GYEAR__, 21(4): 689-700 Back to browse issues page
The effect of Acetaminophen, Aspirin and Ibuprofen on the rate of orthodontic tooth movement and root resorption in rabbits
Massoud Seifi Corresponding Author: Dr. * , Mahdi Ravadgar Dr., Behnam Eslami Dr.
Assistant Prof.
Abstract:   (5833 Views)

Aim: The purpose of this study was to compare the effect of three common NSAIDs drugs including Acetaminophen, Aspirin and Ibuprofen on the rate of orthodontic tooth movement and root resorption in rabbits.

Method & Materials: The study was performed experimentally through observation and questionnaire. 24 Male New Zealand white rabbits ranging in weight from 1.35-2.5kg were randomly assigned into one of the three test groups or a control group, each consisting of 6 animals. Under anesthesia NiTi closed coil spring were ligated between the left side mandibular incisor and 1st molar. Closed coil spring delivering 6 oz force. Acetaminophen group received 200 mg/kg of drug (Tablet) in one dose per day. Aspirin group received 100 mg/kg of drug (Tablet) in one dose per day. Ibuprofen group received 10mg/kg of drug (Suspension) in one dose per day. Control group received no drug during this study. The animals were sacrificed after 1 month and orthodontic tooth movement of 1st molar was measured with special gauges with 0.05mm accuracy. After histological processing, Sections of each group (mesio-distal sections) were prepared and mid-root sections were chosen to calculate root resorption on mesial surface of 1st molar with computerized histomorphometric method. Analysis of variance (ANOVA) was performed to assess tooth movement and root resorption and multiple comparisons analysis was used to compare different groups.

Results: Control and acetaminophen groups exhibited similar degree of tooth movement which had significant difference with Ibuprofen and aspirin groups (P<0.001). Aspirin group exhibited least root resorption which was significantly different with other groups (P<0.05).

Conclusion: Acetaminophen had no effect on rate of tooth movement but Aspirin and Ibuprofen decreased rate of tooth movement. Aspirin therapy may decrease the risk of root resorption during orthodontic treatments.

J Dent Sch 2004 21(Special Issue): 689

Keywords: NSAIDs, Acetaminophen, aspirin, Ibuprofen, root resorption rabbit
Full-Text [PDF 408 kb]   (1595 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2006/09/6
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Seifi M, Ravadgar M, Eslami B. The effect of Acetaminophen, Aspirin and Ibuprofen on the rate of orthodontic tooth movement and root resorption in rabbits. J Dent Sch. 2004; 21 (4) :689-700
URL: http://jds.sbmu.ac.ir/article-1-628-en.html


Volume 21, Issue 4 (Winter (Special Issue) 2004) Back to browse issues page
مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی Shahid Beheshti University Dental Journal
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