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:: Volume 26, Issue 4 (Winter 2009) ::
J Dent Sch GYEAR__, 26(4): 363-368 Back to browse issues page
Relationship between Interleukin 4 and 12 and chronic periapical lesion size
Mandana Sattari Corresponding Author: Dr. * 1, Haniyeh Nazarinia Dr.2, Saeed Khalili , Mohammad Asna-Ashari Dr., Ali Kangarloo Dr.
1- , mandana.sattari@gmail.com
2- Mcgill، Canada.
Abstract:   (4897 Views)

Background and Aim: Chronic dental periapical lesions resulted from chronic inflammatory response to the periapical tissues. Since T-helper (CD4+Y) cells are the prominent cells in these lesions, so the aim of this study was to determine the correlation between the concentration of IL-4 and IL-12 (most important cytokines for differentiation of T helper 2 and T helper 1 cells, respectively), and the diameter of chronic periapical lesions.

Materials & Methods: Thirty-eight chronic periapical lesions were collected which 18 periapical lesions had diameter of ≥5 millimeter (case group) and 20 periapical lesions had the diameter <5 millimeter (control group). Tissue samples were cultured for 72 hours, then ELISA (Enzyme linked immuno-sorbent Assay) was used for determining the concentration of IL-4 and IL-12 in supernatant fluids. Mann-whitney U and Spearman correlation tests were used to analyze the data.

Results: IL-4 and IL-12 were found in all of samples. There was no significant difference between case and control groups regarding the concentration of IL-4, IL-12 and IL-4/IL-12. The only significant correlation was between IL-4 and IL-6 concentration without any regard to the diameter of lesions (P<0.001) (Spearman correlation coefficient= 0.593).

Conclusion: It is concluded that in chronic periapical lesions, probably T helper 1 and T helper 2 cells participate in active phases of inflammation and tissue damage equally. This could be resulted from mixed population of bacteria in these lesions.

J Dent Sch 2008 26(4): 4 

Keywords: T - helper, Chronic periapical lesions, Interleukin-4, Interleukin-12
Full-Text [PDF 199 kb]   (1059 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2006/09/6
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Sattari M, Nazarinia H, Khalili S, Asna-Ashari M, Kangarloo A. Relationship between Interleukin 4 and 12 and chronic periapical lesion size. J Dent Sch. 2009; 26 (4) :363-368
URL: http://jds.sbmu.ac.ir/article-1-401-en.html


Volume 26, Issue 4 (Winter 2009) Back to browse issues page
مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی Shahid Beheshti University Dental Journal
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