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:: Volume 26, Issue 4 (Winter 2009) ::
J Dent Sch GYEAR__, 26(4): 355-362 Back to browse issues page
Evaluation of Adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma by immunohistochemistry
Nasrollah Saghravanian Corresponding Author: Dr. *1, Nooshin Mohtasham Dr., Mohammad Taghi Shakeri Dr.
1- , sagravanian@mums.ac.ir
Abstract:   (7993 Views)

Background and Aim: Salivary gland tumors classification continuously undergoes alternations, especially in the recent years. This study used immunohistochemical markers for distinguishing between polymorphous low-grade adenocarcinoma (PLGA) and adenocarcinoma carcinoma (AdCC) which have several overlapping histological and clinical features.

Materials & Methods: Ten AdCC and eight PLGA with five normal minor salivary glands were selected after review by two oral pathologists. LSAB method was used for seven markers: carcinoembryonic antigen, epithelial membrane antigen, muscle specific actin, vimentin, S100, P53 and Ki-67. Finally, the data were analyzed by Mann-Whiteny test.

Results: Analysis of data showed a high expression of CEA, EMA and Ki-67 in AdCC compared to PLGA. Although, CEA (P<0.001) expression was limited to luminal cells .In contrast, MSA (P=0.034) expression in nonluminal cells, and Ki-67 (P<0.001) occurred in both luminal and nonluminal cells. Also there was highly expression of vimentin and S-100 in PLGA with no significancy for EMA and Tp53.

Conclusion: The result of this study suggests that ICH can be a helpful tool. The immunostaining of AdCC and PLGA with CEA, Vimentin and Ki-67 were of greater significant, S100 and MSA were less significant and the others (EMA and P53) could not offer an adjunctive aid in differential diagnosis between the two tumors.

J Dent Sch 2008 26(4): 3

Keywords: Adenoid cystic carcinoma, Polymorphous low-grade adenocarcinoma, Immunohistochemstry
Full-Text [PDF 234 kb]   (1317 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2006/09/6
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Saghravanian N, Mohtasham N, Shakeri M T. Evaluation of Adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma by immunohistochemistry. J Dent Sch. 2009; 26 (4) :355-362
URL: http://jds.sbmu.ac.ir/article-1-400-en.html


Volume 26, Issue 4 (Winter 2009) Back to browse issues page
مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی Shahid Beheshti University Dental Journal
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