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:: دوره 36، شماره 1 - ( 12-1396 ) ::
جلد 36 شماره 1 صفحات 27-31 برگشت به فهرست نسخه ها
Comparison of the Effects of Local Injection and Oral Intake of Diclofenac and Atorvastatin in Alveolar Bone Density Assessed with CT in Experimental Periodontitis in Rat
چکیده:   (336 مشاهده)
Objectives The first cause of tooth loss in developed countries is periodontitis. Chronic periodontitis is the most common
form of periodontitis and it is characterized by loss of periodontal attachment, destruction of alveolar bone and
eventual loss of teeth. Atorvastatin is a statin drug used for the treatment of high cholesterol. Statins can stop the
inflammatory process by inhibiting the cholesterol pathway. Diclofenac is an NSAID with anti-inflammatory, anti
pyretic and analgesic effects. Its primary mechanism is through the inhibition of prostaglandins synthesis by the
inhibition of the cyclooxygenase enzyme (COX). The purpose of this study is to compare the effects of local injected
and oral intake of Diclofenac and atorvastatin on alveolar bone density measured in HUs with the use of a CT scan in a
periodontitis-induced model in rats.

Methods Thirty rats were randomly divided into 6 groups of 5 rats each. Ligatures were placed around the left second
maxillary molar to induce periodontitis for 10 days. Administration of 12.5 mg/kg of oral atorvastatin (group 1), 0.25
mg/kg of injectable atorvastatin (group 2), 7.5mg/kg of oral Diclofenac (group 3), 6.25mg/kg of injectable Diclofenac
(group 4), the oral solvent without medicine as oral control (groups 5), and the injectable solvent without medicine
as injectable control (group 6). In each group, the right side of maxilla was considered as control group (without
ligature and drug interaction). At day eleven, the rats were sacrificed and the maxillary bone was separated from the
soft tissue and fixed in 4% formalin. The prepared samples were then radiologically evaluated to determine the bone
density with CT in fixed exposure conditions.

Results There was a statistically significant difference between the alveolar bone density of the oral atorvastatin
group and the oral Diclofenac (P = 0.006). There was no statistical significant difference in alveolar bone density
between the injectable atorvastatin and the injectable Diclofenac groups (P=0.228).

Conclusion Both atorvastatin and Diclofenac have shown better results when assessing bone density in a periodontitis rat
model as compared to controls. Additionally, Diclofenac has been shown to be more effective at both oral and injectable
administrations as compared with atorvastatin in the prevention of loss of bone density in a rat model with periodontitis.
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نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: ۱۳۹۷/۴/۳۰ | پذیرش: ۱۳۹۷/۴/۳۰ | انتشار: ۱۳۹۷/۴/۳۰
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Masoumia S, Carassquer C P, Setoudehmaramc S, Moatari M, Tanideh N. Comparison of the Effects of Local Injection and Oral Intake of Diclofenac and Atorvastatin in Alveolar Bone Density Assessed with CT in Experimental Periodontitis in Rat. J Dent Sch. 2018; 36 (1) :27-31
URL: http://jds.sbmu.ac.ir/article-1-1669-fa.html

Comparison of the Effects of Local Injection and Oral Intake of Diclofenac and Atorvastatin in Alveolar Bone Density Assessed with CT in Experimental Periodontitis in Rat. مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی. 1396; 36 (1) :27-31

URL: http://jds.sbmu.ac.ir/article-1-1669-fa.html



دوره 36، شماره 1 - ( 12-1396 ) برگشت به فهرست نسخه ها
مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی Shahid Beheshti University Dental Journal
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