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:: دوره 35، شماره 4 - ( 9-1396 ) ::
جلد 35 شماره 4 صفحات 127-132 برگشت به فهرست نسخه ها
The effects of local and systemic Atorvastatin on inflammation and alveolar bone loss in experimental periodontitis in rats
چکیده:   (725 مشاهده)
Objectives The frst cause of tooth loss in developed countries is periodontitis and mostly occurs in people over 40 years old.Atorvastatin
is a statin drug class, which has a revolutionary impact on the treatment of high cholesterol and also stimulates bone
morphogenic protein which has osteogenic potential. The aim of this study was to evaluate the effect of local and systemic Atorvastatin in
the treatment of periodontitis.

Materials and Methods Forty eight Sprague Dawley rats were randomly divided into six groups of eight in each; experimental periodontitis
was induced by ligature in fve of them in each group daily (1) systemic Atorvastatin 12.5 mg/kg (2) systemic solvent (3) local Atorvastatin
0.25 mg/kg (4) local solvent (5) no drug was administered and group (6) left non-ligated, and rats were sacrifced on 11th day.
Histopathological analysis on periodontal tissue; malondialdehyde (MDA) and superoxide dismutase (SOD) tests on serum were performed
to investigate bone loss and inflammation. The statistical tests for MDA and SOD samples were one-way ANOVA with Duncan post-hoc
whereas in histopathological samples nonparametric Kruskal–Wallis and Mann–Whitney tests were used.

Results Although local injection and oral administration of Atorvastatin signifcantly decreased alveolar bone loss and serum MDA levels,
no signifcant difference in their effectiveness was observed. Serum SOD levels were not signifcantly changed in all administered groups.

P-value < 0.05.
Conclusion In this study, both local injection and oral forms of Atorvastatin decreased inflammation and bone loss in periodontitis. However,
no signifcant difference in their effectiveness was detected. However, local injection is superior to oral form due to effective lower dose.
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نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: ۱۳۹۷/۲/۳۱ | پذیرش: ۱۳۹۷/۲/۳۱ | انتشار: ۱۳۹۷/۲/۳۱
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Masoumi S, Kouzeforush Abadi K, Setoudehmaram S, Tanideh N, Movahed B. The effects of local and systemic Atorvastatin on inflammation and alveolar bone loss in experimental periodontitis in rats. J Dent Sch. 2017; 35 (4) :127-132
URL: http://jds.sbmu.ac.ir/article-1-1642-fa.html

The effects of local and systemic Atorvastatin on inflammation and alveolar bone loss in experimental periodontitis in rats. مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی. 1396; 35 (4) :127-132

URL: http://jds.sbmu.ac.ir/article-1-1642-fa.html



دوره 35، شماره 4 - ( 9-1396 ) برگشت به فهرست نسخه ها
مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی Shahid Beheshti University Dental Journal
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