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:: Volume 24, Issue 1 (Spring 2006) ::
J Dent Sch GYEAR__, 24(1): 102-107 Back to browse issues page
Correlation of Neutrophil Chemotaxis and Dental Caries
Mandana Sattari Corresponding Author: Dr. *, Maryam Basirat Dr., Amir Ghassemi Dr., Shide Mehre Mofakham
Associate Prof. , mandanasattari@yahoo.com
Abstract:   (21698 Views)

Background & Aim: In addition to microorganisms, several other factors such as host immune responses are also involved in pathogenesis of dental caries. Among the factors of immune system, the role of neutrophil in prevention or pathogenesis of dental caries is not well studied. So the aim of this study was to investigate the correlation of neutrophil chemotaxis and dental caries.

Methods & Materials: In this analytical study, fifty dental students with dental caries were selected. 10 ml of heparinized blood were collected from subjects for neutrophil chemotaxis test by modified Boyden chamber method. Statistical analysis was made by ANOVA, t test and Pearson's correlation coefficient.

Results: The amount of neutrophil chemotaxis in the above subjects was 94.38± 12.08 micrometer. Statistical analysis did not show any significant difference regarding to neutrophil chemotaxis in different degrees of DMF. But by comparing neutrophil chemotaxis with the degree of active caries, significant differences were shown between 0 and 5 degrees (P ≈ 0.000) and 1 and 5 degrees (P ≈ 0.016) of active caries regarding to the mean of neutrophil chemotaxis.

Conclusion: It is suggested that not only deficiency in neutrophil chemotaxis is not assumed in pathogenesis of dental caries, but also there is a direct correlation between neutrophil chemotaxis and the degree of active caries. Of course more studies are needed in order to prove this hypothesis.

J Dent Sch 2006 24(1): 16 

Keywords: Dental Caries, Neutrophil, Chemotaxis
Full-Text [PDF 235 kb]   (929 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2006/09/6
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Sattari M, Basirat M, Ghassemi A, Mehre Mofakham S. Correlation of Neutrophil Chemotaxis and Dental Caries. J Dent Sch. 2006; 24 (1) :102-107
URL: http://jds.sbmu.ac.ir/article-1-79-en.html
Volume 24, Issue 1 (Spring 2006) Back to browse issues page
مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی Shahid Beheshti University Dental Journal
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