[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 36, Issue 1 (winter 2018) ::
J Dent Sch GYEAR__, 36(1): 27-31 Back to browse issues page
Comparison of the Effects of Local Injection and Oral Intake of Diclofenac and Atorvastatin in Alveolar Bone Density Assessed with CT in Experimental Periodontitis in Rat
Sara Masoumia 1, Carlos Parra Carassquer * 2, Shahin Setoudehmaramc 3, Maryam Moatari 4, Nader Tanideh 5
1- Dept. of Periodontics and Implant, Dental School, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Dept. of Periodontics, Texas A & M University College of Dentistry, Dallas, TX, USA. , cparra@tamhsc.edu
3- c Orthodontic Research Center, Dental School, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Private Practice, Shiraz, Iran.
5- Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (491 Views)
Objectives The first cause of tooth loss in developed countries is periodontitis. Chronic periodontitis is the most common
form of periodontitis and it is characterized by loss of periodontal attachment, destruction of alveolar bone and
eventual loss of teeth. Atorvastatin is a statin drug used for the treatment of high cholesterol. Statins can stop the
inflammatory process by inhibiting the cholesterol pathway. Diclofenac is an NSAID with anti-inflammatory, anti
pyretic and analgesic effects. Its primary mechanism is through the inhibition of prostaglandins synthesis by the
inhibition of the cyclooxygenase enzyme (COX). The purpose of this study is to compare the effects of local injected
and oral intake of Diclofenac and atorvastatin on alveolar bone density measured in HUs with the use of a CT scan in a
periodontitis-induced model in rats.

Methods Thirty rats were randomly divided into 6 groups of 5 rats each. Ligatures were placed around the left second
maxillary molar to induce periodontitis for 10 days. Administration of 12.5 mg/kg of oral atorvastatin (group 1), 0.25
mg/kg of injectable atorvastatin (group 2), 7.5mg/kg of oral Diclofenac (group 3), 6.25mg/kg of injectable Diclofenac
(group 4), the oral solvent without medicine as oral control (groups 5), and the injectable solvent without medicine
as injectable control (group 6). In each group, the right side of maxilla was considered as control group (without
ligature and drug interaction). At day eleven, the rats were sacrificed and the maxillary bone was separated from the
soft tissue and fixed in 4% formalin. The prepared samples were then radiologically evaluated to determine the bone
density with CT in fixed exposure conditions.

Results There was a statistically significant difference between the alveolar bone density of the oral atorvastatin
group and the oral Diclofenac (P = 0.006). There was no statistical significant difference in alveolar bone density
between the injectable atorvastatin and the injectable Diclofenac groups (P=0.228).

Conclusion Both atorvastatin and Diclofenac have shown better results when assessing bone density in a periodontitis rat
model as compared to controls. Additionally, Diclofenac has been shown to be more effective at both oral and injectable
administrations as compared with atorvastatin in the prevention of loss of bone density in a rat model with periodontitis.
Keywords: Atorvastatin, Diclofenac, Alveolar Bone Loss, Bone Density, Rat
Full-Text [PDF 446 kb]   (88 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2018/07/21 | Accepted: 2018/07/21 | Published: 2018/07/21
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Masoumia S, Carassquer C P, Setoudehmaramc S, Moatari M, Tanideh N. Comparison of the Effects of Local Injection and Oral Intake of Diclofenac and Atorvastatin in Alveolar Bone Density Assessed with CT in Experimental Periodontitis in Rat. J Dent Sch. 2018; 36 (1) :27-31
URL: http://jds.sbmu.ac.ir/article-1-1669-en.html


Volume 36, Issue 1 (winter 2018) Back to browse issues page
مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی Shahid Beheshti University Dental Journal
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3781