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:: Volume 35, Issue 4 (Fall 2017) ::
J Dent Sch GYEAR__, 35(4): 122-126 Back to browse issues page
Expression of CK8 and CK17, Specific Epithelial Markers, by Oral Squamous Cell Carcinoma Cell Lines
Fatemeh Mashhadiabbas *1, Mozhgan Shavakhi2, Hamid Nazarian3, Parisa Kardouni Khoozestani4, Hamidreza Moslemi5
1- Oral and Maxillofacial Pathology Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Orthodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Oral and Maxillofacial Pathology Department, Gilan University of Medical Sciences, Rasht, Iran
5- Students’ Research Committee, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (1076 Views)
Objectives Oral squamous cell carcinoma (OSCC) is among the most common cancers worldwide. This study aimed to assess the expression
of CK8 and CK17 by OSCC cell lines in Iranian patients.

Methods This observational study was conducted on three OSCC cell lines with a minimum of 45 passages. Cells isolated from three
patients with OSCC were cultured and passaged. Expression of CK8 and CK17 epithelial markers was assessed using reverse-transcription
polymerase chain reaction. Data were presented qualitatively.

Results The results confrmed the expression of CK8 and CK17 mRNA in three groups. Expression of these markers was different in the three
specimens based on their degree of malignancy.

Conclusion Since CK8 and CK17 were expressed in different superfcial and basal layers in the three specimens, epithelial origin of these cells
was confrmed. This study can pave the way for further cancer research and designing new treatments.
Keywords: Carcinoma, Squamous Cell, Mouth, Cell Line
Full-Text [PDF 1475 kb]   (180 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2018/05/21 | Accepted: 2018/05/21 | Published: 2018/05/21
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Mashhadiabbas F, Shavakhi M, Nazarian H, Kardouni Khoozestani P, Moslemi H. Expression of CK8 and CK17, Specific Epithelial Markers, by Oral Squamous Cell Carcinoma Cell Lines. J Dent Sch. 2017; 35 (4) :122-126
URL: http://jds.sbmu.ac.ir/article-1-1641-en.html


Volume 35, Issue 4 (Fall 2017) Back to browse issues page
مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی Shahid Beheshti University Dental Journal
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