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:: Volume 34, Issue 1 (winter 2016) ::
J Dent Sch GYEAR__, 34(1): 58-65 Back to browse issues page
Immunohistochemical Expression of PCNA and Ki-67 in Periapical Granuloma and Radicular Cyst
S. Sargolzaei *, A. Roufegarinejad , S. Shamszadeh
1Assistant Professor , soudabehsargolzaei@gmail.com
Abstract:   (1367 Views)

Objectives: Periapical Granulomas (PGs) and Radicular Cysts (RCs), as the most common odontogenic lesions have yet unclear pathogenesis. This study was aimed to compare PCNA and Ki-67 expression in PGs and RCs and evaluate their possible relationship with two lesions.

Methods: In this cross-sectional descriptive study, twenty PGs and twenty RCs were evaluated immunohistochemically using an anti-PCNA and anti-Ki-67 polyclonal antibodies. PCNA+ and Ki-67+ cells were counted in connective tissue wall and epithelial lining (in RCs). Statistical analysis was performed by using Mann-Whitney U test and Spearman’s rank correlation coefficient.

Results: In PGs, percentage of PCNA and Ki-67 expression were found 70% and 30%, respectively; In RCs, PCNA and Ki-67 expression were observed 90% and 55%, respectively. Additionally, in RCS, Immunoexpression of PCNA (85%) and Ki-67 (60%) were detected at epithelial lining area. The positive immunoexpression of PCNA in RCs was greater than PGs (p<0.05).

Conclusion: Immunoexpression of PCNA and Ki-67 were detected in both lesions which may be mentioned as valuable markers for the prediction of biologic behavior of PGs and RCs.

Keywords: Immunohistochemistry, Ki-67, PCNA, Periapical Granuloma, Radicular Cyst.
Full-Text [PDF 464 kb]   (270 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2015/05/6 | Accepted: 2015/11/14
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Sargolzaei S, Roufegarinejad A, Shamszadeh S. Immunohistochemical Expression of PCNA and Ki-67 in Periapical Granuloma and Radicular Cyst. J Dent Sch. 2016; 34 (1) :58-65
URL: http://jds.sbmu.ac.ir/article-1-1478-en.html
Volume 34, Issue 1 (winter 2016) Back to browse issues page
مجله دانشکده دندانپزشکی دانشگاه علوم پزشکی شهید بهشتی Shahid Beheshti University Dental Journal
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